Esnakula Ashwini K, Mummidi Sudhir K, Oneal Patricia A, Naab Tammey J
Department of Pathology, Howard University Hospital, Washington, DC, USA.
BMJ Case Rep. 2013 May 2;2013:bcr2013009159. doi: 10.1136/bcr-2013-009159.
Infections are a significant cause of morbidity and mortality in patients with sickle cell disease. Loss of splenic function in these patients makes them highly susceptible to some bacterial infections. Non-tuberculous mycobacterial infections in patients with sickle cell disease are extremely rare and only two cases have been reported previously. We describe a case of sepsis caused by non-tuberculous mycobacterium, Mycobacterium terrae complex in a patient with febrile sickle cell disease. M terrae complex is a rare clinical pathogen and this is the first reported case of sepsis secondary to this organism in a patient with sickle cell disease. The patient responded to imipenem and amikacin therapy.
感染是镰状细胞病患者发病和死亡的重要原因。这些患者脾脏功能丧失，使其极易受到某些细菌感染。镰状细胞病患者的非结核分枝杆菌感染极为罕见，此前仅报告过两例。我们描述了一例由非结核分枝杆菌地分枝杆菌复合群引起的脓毒症病例，该患者患有发热性镰状细胞病。地分枝杆菌复合群是一种罕见的临床病原体，这是首次报道镰状细胞病患者继发于该病原体的脓毒症病例。患者对亚胺培南和阿米卡星治疗有反应。
