Bodle Ethan E, Cunningham Jennifer A, Della-Latta Phyllis, Schluger Neil W, Saiman Lisa
Columbia University, New York, New York, USA.
Emerg Infect Dis. 2008 Mar;14(3):390-6. doi: 10.3201/eid1403.061143.
We reviewed medical records of patients without known HIV and with positive cultures for nontuberculous mycobacteria (NTM) isolated during 2000-2003 from 1 large hospital in New York, New York. Overall, 505 patients had positive NTM cultures; 119 (24%) met the criteria for NTM disease. The difference between demographic characteristics of case-patients in our study (66% female, 61% white, and 59% > 60 years of age) and those of the base population as determined by regional census data was statistically significant. Estimated incidences for positive cultures, all disease, and respiratory tract disease were 17.7, 2.7, and 2.0 per 100,000 persons, respectively. More patients with rapidly growing mycobacteria (61%), Mycobacterium kansasii (70%), or M. marinum (100%) met criteria for disease than did patients with M. avium complex (MAC) (27%, (p < 0.01). NTM disease in patients without HIV is increasing. Laboratory-based surveillance may be useful for detecting non-MAC and non-respiratory tract disease.
我们回顾了2000年至2003年期间从纽约市一家大型医院分离出的非结核分枝杆菌（NTM）培养呈阳性且无已知艾滋病毒的患者的病历。总体而言，505例患者NTM培养呈阳性；119例（24%）符合NTM病的标准。我们研究中病例患者的人口统计学特征（66%为女性，61%为白人，59%年龄>60岁）与区域人口普查数据确定的基础人群特征之间的差异具有统计学意义。阳性培养、所有疾病和呼吸道疾病的估计发病率分别为每10万人17.7、2.7和2.0。与鸟分枝杆菌复合群（MAC）患者（27%，p<0.01）相比，快速生长分枝杆菌患者（61%）、堪萨斯分枝杆菌患者（70%）或海分枝杆菌患者（100%）符合疾病标准的更多。无艾滋病毒患者的NTM病正在增加。基于实验室的监测可能有助于检测非MAC和非呼吸道疾病。
