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[光动力疗法的新趋势与安全性]

[New trends and safety of photodynamic therapy].

作者信息

Osmałek Tomasz, Gośliński Tomasz, Mielcarek Jadwiga, Osmałek Edyta

机构信息

Katedra i Zakład Technologii Postaci Leku, Uniwersytet Medyczny im. K. Marcinkowskiego w Poznaniu.

出版信息

Przegl Lek. 2012;69(11):1205-8.

Abstract

Photodynamic therapy (PDT) is used mainly in tumor diagnosis and treatment. It is obvious that PDT can increase the efficiency of traditional methods such as surgery, chemotherapy or radiotherapy. Unfortunately, photosensitizers used in the treatment are still imperfect. According to severe side effects, patients need to change their life habits even for several weeks. The problem is attributed to insufficient selectivity of dyes toward cancer tissues. Safety of PDT can be improved by application of various carriers including liposomes, nanotubes or nanoparticles. Binding of photosensitizers to tumor specific molecules opens broad new possibilities for PDT.

摘要

光动力疗法(PDT)主要用于肿瘤的诊断和治疗。很明显,光动力疗法可以提高手术、化疗或放疗等传统方法的效率。不幸的是,治疗中使用的光敏剂仍然存在缺陷。由于严重的副作用,患者甚至需要在几周内改变生活习惯。这个问题归因于染料对癌组织的选择性不足。通过应用包括脂质体、纳米管或纳米颗粒在内的各种载体,可以提高光动力疗法的安全性。将光敏剂与肿瘤特异性分子结合为光动力疗法开辟了广阔的新前景。

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