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用于光动力疗法的金纳米颗粒挖掘:对微小纳米颗粒寄予厚望。

Gold mining for PDT: Great expectations from tiny nanoparticles.

作者信息

Gamaleia Nikolai F, Shton Irina O

机构信息

Laboratory of Quantum Nanobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasylkivska Str., Kyiv 03022, Ukraine.

Laboratory of Quantum Nanobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasylkivska Str., Kyiv 03022, Ukraine.

出版信息

Photodiagnosis Photodyn Ther. 2015 Jun;12(2):221-31. doi: 10.1016/j.pdpdt.2015.03.002. Epub 2015 Mar 26.

Abstract

Among many and various products, born by the modern nanotechnology, gold nanoparticles roused a special interest of biomedical researchers. Unique features of the nanoparticles allow to use them not only as effective transporters for therapeutic agents but also as basic components of nanocomposite preparations intended for targeted photodynamic and photothermal therapy of tumours. In the review, physical, chemical and biological properties of gold nanoparticles which can promote PDT efficiency of a designed nanocomposite, are briefly characterized, and promising trends in creation of gold-containing composite photosensitizers are analysed.

摘要

在现代纳米技术所产生的众多不同产品中,金纳米颗粒引起了生物医学研究人员的特别关注。纳米颗粒的独特特性使其不仅可以用作治疗剂的有效转运载体,还可以作为用于肿瘤靶向光动力和光热治疗的纳米复合制剂的基本成分。在这篇综述中,简要描述了可提高设计的纳米复合材料光动力疗法(PDT)效率的金纳米颗粒的物理、化学和生物学特性,并分析了含金复合光敏剂制备方面的前景趋势。

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