Roblero-Bartolón Gabriela Victoria, Ramón-Gallegos Eva
Laboratorio de Citopatología Ambiental, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas-IPN, Campus Zacatenco, Unidad Profesional «Adolfo López Mateos», México, D.F.
Gac Med Mex. 2015 Jan-Feb;151(1):85-98.
Nanotechnology is a promising interdisciplinary field for developing improved methods of diagnosis and treatment of different diseases, including cancer. Give their optical, magnetic, and structural property, the nanoparticles have been proposed to be use in the development of unconventional treatments for cancer such as photodynamic therapy (PDT). In PDT, a photosensitizing agent is used that accumulates in tumor cells, generating reactive oxygen species that causes the death of malignant cells after irradiation with light at a particular wavelength. However, the use of PDT presents different problems in its application due to the characteristics of hydrophobicity of the photosensitizers, which hinder the efficiency of administration and treatment. It is here where the use of nanoparticles is proposed as a delivery vehicle to optimize treatment application. In this review we describe the use of nanoparticles coupled to PDT in the treatment of cancer and its molecular mechanism of action.
纳米技术是一个很有前景的跨学科领域，可用于开发改进的不同疾病（包括癌症）的诊断和治疗方法。鉴于其光学、磁性和结构特性，纳米颗粒已被提议用于开发诸如光动力疗法（PDT）等非传统癌症治疗方法。在光动力疗法中，使用一种光敏剂，该光敏剂在肿瘤细胞中积累，产生活性氧，在特定波长的光照射后导致恶性细胞死亡。然而，由于光敏剂的疏水性特征，光动力疗法在其应用中存在不同问题，这阻碍了给药和治疗的效率。正是在此处，提议使用纳米颗粒作为递送载体来优化治疗应用。在本综述中，我们描述了与光动力疗法相结合的纳米颗粒在癌症治疗中的应用及其分子作用机制。
