[大黄粉对脑出血患者血清补体3、补体4及超敏C反应蛋白的影响]

[Effects of rhubarb powder on serum complement 3, complement 4, and hs-CRP in patients with intracerebral hemorrhage].

作者信息

Yong-Jun Fang, Yi Zhang, Zun-Hua Ke, Zhen-Guo Zhou, Feng Zhou, Lu-Ning Bai

机构信息

Faculty of Surgery, College of Clinical Medicine, Shaanxi College of Traditional Chinese Medicine, Shaanxi, China.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Feb;33(2):168-71.

PMID:23646468

Abstract

OBJECTIVE

To investigate the effects of rhubarb powder on serum complement 3 (C3), complement 4 (C4), and hypersensitive C-reactive protein (hs-CRP) levels in patients with hypertensive intracerebral hemorrhage (HICH) after operation.

METHODS

Forty inpatients with HICH after operation were recruited from Department of Cerebral Surgery, Affiliated Hospital of Shaanxi College of Traditional Chinese Medicine from July 2009 to March 2010. They were randomly assigned to the treatment group (20 cases) and the control group (20 cases). From the 4th day after surgery, all patients received routine Western medical treatment. The rhubarb powder, 5-10 g dissolving in 40 mL warm water, was administered or nasally fed to those in the treatment group, 2 -3 times daily for 10 successive days. The contents of serum C3, C4, and hs-CRP were detected in the two groups on the 7th day and the 14th day after operation. The serum hs-CRP content was detected using latex particle enhanced immunoturbidimetric assay. The Scandinavia Stroke Scale (SSS) scores were recorded in the two groups.

RESULTS

Compared with the same group on the 4th day after operation, the levels of serum C3 and C4 increased on the 7th day after operation, and SSS score increased on the 14th day after operation in the control group (P < 0.05). The contents of C4 and hs-CRP decreased, and the SSS score increased on the 14th day after operation in the treatment group (P < 0.05). Compared with the same group on the 7th day after operation, the contents of C4 and hs-CRP decreased and the SSS score increased on the 14th day after operation in the treatment group (P < 0.05). Compared with the control group at the same time points, the contents of C4 and C3 decreased on the 7th day after operation; the contents of C3, C4, and hs-CRP decreased, and SSS score increased in the treatment group on the 14th day after operation (P < 0.05).

CONCLUSION

The rhubarb powder could significantly decrease the serum levels of C3, C4, and hs-CRP, and improve the curative effect in patients with HICH after operation.

摘要

目的

探讨大黄粉对高血压脑出血（HICH）患者术后血清补体3（C3）、补体4（C4）及超敏C反应蛋白（hs-CRP）水平的影响。

方法

选取2009年7月至2010年3月陕西中医学院附属医院脑外科收治的40例HICH术后住院患者，随机分为治疗组（20例）和对照组（20例）。术后第4天起，所有患者均接受西医常规治疗。治疗组患者给予大黄粉5 - 10 g溶于40 mL温水中，口服或鼻饲，每日2 - 3次，连续服用10天。分别于术后第7天和第14天检测两组患者血清C3、C4及hs-CRP含量。血清hs-CRP含量采用乳胶颗粒增强免疫比浊法检测。记录两组患者的斯堪的纳维亚卒中量表（SSS）评分。

结果

对照组术后第7天血清C3、C4水平较术后第4天升高，术后第14天SSS评分升高（P < 0.05）。治疗组术后第14天C4及hs-CRP含量降低，SSS评分升高（P < 0.05）。治疗组术后第14天C4及hs-CRP含量较术后第7天降低，SSS评分升高（P < 0.05）。术后第7天，治疗组C4、C3含量较对照组降低；术后第14天，治疗组C3、C4、hs-CRP含量降低，SSS评分升高（P < 0.05）。