病理性近视患者的C反应蛋白和补体成分

C-reactive protein and complement components in patients with pathological myopia.

作者信息

Long Qin, Ye Junjie, Li Ying, Wang Shuran, Jiang Yang

机构信息

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Optom Vis Sci. 2013 May;90(5):501-6. doi: 10.1097/OPX.0b013e31828daa6e.

DOI:10.1097/OPX.0b013e31828daa6e

PMID:23538433

Abstract

PURPOSE

To investigate the association between pathological myopia (PM) and immunological/inflammatory markers and to identify the possible risk factors for the formation of myopic choroidal neovascularization (mCNV).

METHODS

One hundred fourteen unrelated subjects were recruited: 63 PM patients (PM group) with spherical equivalent of at least -8.00 diopters (range, -8.00 to -25.00) and axial length exceeding 26.5 mm, accompanied by characteristic pathologic changes, and 51 emmetropic age- and sex-matched individuals (control group) with spherical equivalent within ±1.0 diopter in both eyes. In the PM group, patients were assigned to two subgroups, mCNV group and no CNV group, according to the results of fluorescein angiography. Serum high-sensitivity C-reactive protein (hs-CRP) and complement profile (C3, C4, and CH50) were assayed. Statistical analysis was performed between the two groups. Binary logistic regression analysis was used to analyze the relative risk factors that were associated with the development of mCNV in the PM group patients.

RESULTS

The range of axial length was 26.50 to 37.08 mm in the PM group and 22.32 to 24.56 mm in the control group. There were 24 patients in the mCNV group and 39 patients in the no CNV group. The PM group patients had significantly higher serum hs-CRP (p = 0.033), C3 (p = 0.004), and CH50 (p < 0.001) compared with the control group patients. There were no significant differences between the two groups for C4 level (p = 0.071). Binary logistic regression analysis, which included hs-CRP, C3, C4, CH50, age, and sex as covariates, showed that C3 (p = 0.03) and age (p = 0.01) were risk factors for mCNV, whereas serum hs-CRP, C4, CH50, and sex were not statistically significant predictors of mCNV in the PM group patients (p > 0.05).

CONCLUSIONS

Our data support the hypothesis that immunological/inflammatory markers, namely hs-CRP, C3, and CH50 may play an important role in the development of PM, and that C3 level may be a predictive risk factor for mCNV formation.

摘要

目的

研究病理性近视（PM）与免疫/炎症标志物之间的关联，并确定近视性脉络膜新生血管（mCNV）形成的可能危险因素。

方法

招募了114名无亲属关系的受试者：63名PM患者（PM组），等效球镜度数至少为-8.00屈光度（范围为-8.00至-25.00），眼轴长度超过26.5mm，并伴有特征性病理改变；以及51名年龄和性别匹配的正视个体（对照组），双眼等效球镜度数在±1.0屈光度以内。在PM组中，根据荧光素血管造影结果将患者分为两个亚组，即mCNV组和无CNV组。检测血清高敏C反应蛋白（hs-CRP）和补体谱（C3、C4和CH50）。对两组进行统计学分析。采用二元逻辑回归分析来分析与PM组患者mCNV发生相关的相对危险因素。

结果

PM组的眼轴长度范围为26.50至37.08mm，对照组为22.32至24.56mm。mCNV组有24例患者，无CNV组有39例患者。与对照组患者相比，PM组患者的血清hs-CRP（p = 0.033）、C3（p = 0.004）和CH50（p < 0.001）显著更高。两组之间的C4水平无显著差异（p = 0.071）。将hs-CRP、C3、C4、CH50、年龄和性别作为协变量的二元逻辑回归分析表明，C3（p = 0.03）和年龄（p = 0.01）是mCNV的危险因素，而血清hs-CRP、C4、CH50和性别在PM组患者中不是mCNV的统计学显著预测因素（p > 0.05）。