Laboratoire de Génétique Cellulaire, Institut National de la Recherche Agronomique/ENVT, UMR444, Castanet Tolosan, France.
Anim Genet. 2013 Aug;44(5):579-83. doi: 10.1111/age.12042. Epub 2013 May 6.
Identifying recent positive selection signatures in domesticated animals could provide information on genome response to strong directional selection from domestication and artificial selection and therefore could help in identifying mutations responsible for improved traits. We used genotyping data generated using Illumina's BovineSNP50 Genotyping BeadChips to identify selection signatures in the Blonde d'Aquitaine breed, a well-muscled French beef breed. For this purpose, we employed a hidden Markov model-based test, which detects selection by studying local variations in the allele frequency spectrum along the genome, within a single population. Three regions containing selective sweeps were identified. Annotation of genes located within these regions revealed interesting candidate genes. For example, myostatin (also known as GDF8), a known muscle growth factor inhibitor, is located within the selection signature region found on chromosome 2. In addition, we have identified chromosomal regions that show some evidence of selection within QTL regions for economically important traits. The results of this study could help to better understand the mechanisms related to the selection of the Blonde d'Aquitaine breed.
鉴定家养动物中的近期正选择信号，可以提供有关对驯化和人工选择的强烈定向选择的基因组反应的信息，从而有助于鉴定负责改善性状的突变。我们使用 Illumina 的 BovineSNP50 Genotyping BeadChips 生成的基因分型数据，鉴定了肌肉发达的法国肉牛品种 Blonde d'Aquitaine 品种的选择特征。为此，我们采用了基于隐马尔可夫模型的测试方法，该方法通过研究基因组中单个种群内的等位基因频率谱的局部变化来检测选择。鉴定出三个包含选择清除的区域。位于这些区域内的基因注释揭示了有趣的候选基因。例如，肌肉生长因子抑制剂肌抑素（也称为 GDF8）位于 2 号染色体上发现的选择特征区域内。此外，我们还鉴定了在经济上重要性状的 QTL 区域内显示出选择迹象的染色体区域。这项研究的结果可以帮助更好地理解与 Blonde d'Aquitaine 品种选择相关的机制。
