Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, Milan, Italy.
Future Oncol. 2013 May;9(5):713-26. doi: 10.2217/fon.13.9.
Metastatic melanoma accounts for approximately 80% of skin cancer-related deaths. Up to now there has been no effective treatment for stage IV melanoma patients due to the complexity and dissemination potential of this disease. Melanomas are heterogeneous tumors in which conventional therapies fail to improve overall survival. Targeted therapies are being developed, but the final outcome can be hampered by the incomplete knowledge of the process of melanoma progression. Even if the intracellular pathways are similar, the interaction of the cells with the surrounding environment should be taken into consideration. This article seeks to highlight some of the advances in the understanding of the molecular mechanisms underlying melanoma dissemination.
转移性黑色素瘤约占皮肤癌相关死亡人数的 80%。到目前为止，由于这种疾病的复杂性和传播潜力，对于 IV 期黑色素瘤患者还没有有效的治疗方法。黑色素瘤是异质性肿瘤，常规疗法未能改善总体生存率。目前正在开发靶向疗法，但由于对黑色素瘤进展过程的了解不完整，最终结果可能会受到阻碍。即使细胞内途径相似，也应该考虑细胞与周围环境的相互作用。本文旨在强调对黑色素瘤扩散的分子机制的一些理解进展。
