University of Ljubljana, Veterinary Faculty, Clinic for Reproduction and Horses, Gerbičeva 60, 1000 Ljubljana, Slovenia.
Res Vet Sci. 2013 Oct;95(2):675-7. doi: 10.1016/j.rvsc.2013.03.020. Epub 2013 May 3.
Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway, and is also the only known endogenously synthesized lipid-soluble antioxidant. The aim of the present study was to determine, for the first time, endogenous plasma CoQ10 concentration and its correlation with plasma total antioxidant capacity (TAC) and serum total cholesterol (TC) in a population of healthy untrained horses. Thirty-one horses were included in the study. Plasma CoQ10 concentration ranged from 0.380 to 2.090 mg/L, which is in general agreement with plasma CoQ10 concentration in humans. The study demonstrated no significant correlation between plasma CoQ10 and TAC, which indicates that CoQ10 does not contribute to the TAC of equine plasma significantly. In contrast to humans, no significant correlation was found between CoQ10 and TC in investigated horses. The results warrant further studies on CoQ10 supplementation in healthy untrained horses and subsequent determination of correlations between CoQ10 and TAC.
辅酶 Q10（CoQ10）是线粒体电子传递途径中的必需辅助因子，也是唯一已知的内源性合成脂溶性抗氧化剂。本研究的目的是首次确定健康未经训练的马群中的内源性血浆 CoQ10 浓度及其与血浆总抗氧化能力（TAC）和血清总胆固醇（TC）的相关性。研究纳入了 31 匹马。血浆 CoQ10 浓度范围为 0.380 至 2.090mg/L，与人类血浆 CoQ10 浓度基本一致。研究表明，血浆 CoQ10 与 TAC 之间无显著相关性，这表明 CoQ10 对马血浆的 TAC 无显著贡献。与人类不同的是，在所研究的马匹中，CoQ10 与 TC 之间未发现显著相关性。这些结果需要进一步研究健康未经训练的马匹补充 CoQ10 及其 CoQ10 与 TAC 之间相关性的后续研究。
