1Department of Exercise Physiology and Corrective Movement, Sport Sciences Faculty,Urmia University, Urmia,57561-51818,Iran.
2Department of Internal Medicine and Clinical Pathology, Veterinary Medicine Faculty,Urmia University,Urmia, 57561-51818,Iran.
Br J Nutr. 2018 Feb;119(4):381-390. doi: 10.1017/S0007114517003774.
Strenuous physical exercise and hyperthermia may paradoxically induce oxidative stress and adverse effects on myocardial function. The purpose of this study was to investigate the effect of 14-d coenzyme Q10 (CoQ10) supplementation and pre-cooling on serum creatine kinase-MB (CK-MB), cardiac Troponin I (cTnI), myoglobin (Mb), lactate dehydrogenase (LD), total antioxidant capacity (TAC), lipid peroxidation (LPO) and CoQ10 concentration in elite swimmers. In total, thirty-six healthy males (mean age 17 (sd 1) years) were randomly selected and divided into four groups of supplementation, supplementation with pre-cooling, pre-cooling and control. During an eighteen-session protocol in the morning and evening, subjects attended speed and endurance swimming training sessions for 5 km in each session. Blood sampling was done before (two stages) and after (two stages) administration of CoQ10 and pre-cooling. ANCOVA and repeated measurement tests with Bonferroni post hoc test were used for the statistical analysis of the data. There was no significant statistical difference among groups for the levels of CK-MB, cTnI, Mb, LD, TAC, LPO and CoQ10 at the presampling (stages 1 and 2) (P>0·05). However, pre-cooling and control groups show a significant increase in the levels of CK-MB, cTnI, Mb, LD and LPO compared with the supplementation and supplementation with pre-cooling groups in the post-sampling (stages 1 and 2) (P<0·05), except for the TAC and CoQ10. Consequently, CoQ10 supplementation prevents adverse changes of myocardial damage and oxidative stress during swimming competition phase. Meanwhile, the pre-cooling strategy individually has no desired effect on the levels of CK-MB, cTnI, Mb, LD, LPO, TAC and CoQ10.
剧烈的体力活动和体温过高可能会产生矛盾的效果，导致氧化应激和心肌功能不良。本研究旨在探讨 14 天辅酶 Q10（CoQ10）补充和预冷对优秀游泳运动员血清肌酸激酶同工酶-MB（CK-MB）、心肌肌钙蛋白 I（cTnI）、肌红蛋白（Mb）、乳酸脱氢酶（LD）、总抗氧化能力（TAC）、脂质过氧化（LPO）和 CoQ10 浓度的影响。共随机选择了 36 名健康男性（平均年龄 17 岁（标准差 1 岁）），并将他们分为 4 组：补充组、补充加预冷组、预冷组和对照组。在为期 18 次的清晨和傍晚方案中，受试者参加了速度和耐力游泳训练，每次训练 5 公里。在 CoQ10 和预冷给药前（2 个阶段）和给药后（2 个阶段）进行采血。采用协方差分析和重复测量检验与 Bonferroni 事后检验对数据进行统计分析。在预采样（阶段 1 和 2）时，各组间 CK-MB、cTnI、Mb、LD、TAC、LPO 和 CoQ10 的水平无显著统计学差异（P>0·05）。然而，与补充和补充加预冷组相比，预冷和对照组在采样后（阶段 1 和 2）时 CK-MB、cTnI、Mb、LD 和 LPO 的水平显著升高（P<0·05），但 TAC 和 CoQ10 除外。因此，CoQ10 补充可防止游泳比赛阶段心肌损伤和氧化应激的不良变化。同时，预冷策略单独对 CK-MB、cTnI、Mb、LD、LPO、TAC 和 CoQ10 的水平没有理想的影响。
