Centre for Molecular and Cellular Biology of Inflammation and Peter Gorer Department of Immunobiology, King's College London School of Medicine, London SE1 1UL, UK.
Dev Comp Immunol. 2014 Jan;42(1):57-66. doi: 10.1016/j.dci.2013.04.013. Epub 2013 May 3.
The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.
果蝇 Drosophila melanogaster 已成为研究针对细胞内病原体固有免疫的强大模型。为了对抗感染，果蝇依赖于多种防御机制，其中许多与哺乳动物和人类疾病的节肢动物载体共享。除了保守的免疫途径外，进行复杂遗传筛选的简便性还允许鉴定新的宿主免疫因子和新的病原体毒力因子。最近，一些小组利用这一点同时分析细胞内感染的宿主和病原体遗传学。这篇综述旨在阐明果蝇对细胞内病原体的免疫反应，强调最近的发现。
