University of Colorado, Boulder, CO 80309, USA.
IEEE Trans Biomed Eng. 2013 Sep;60(9):2552-8. doi: 10.1109/TBME.2013.2260542. Epub 2013 Apr 29.
Fusion of biological tissues through direct and indirect heating is a growing area of medical research, yet there are still major gaps in understanding this procedure. Several companies have developed devices which fuse blood vessels, but little is known about the tissue's response to the stimuli. The need for accurate measurements of tissue behavior during tissue fusion is essential for the continued development and improvement of energy delivery devices. An experimental study was performed to measure the temperatures experienced during tissue fusion and the resulting burst pressure of the fused arteries. An array of thermocouples was placed in the lumen of a porcine splenic artery segment and sealed using a ConMed Altrus thermal fusion device. The temperatures within the tissue, in the device, and at the tissue-device interface were recorded. These measurements were then analyzed to calculate the temperature profile in the lumen of the artery. The temperature in the artery at the site of tissue fusion was measured to range from 142 to 163 °C using the ConMed Altrus. The corresponding burst pressure for arteries fused at this temperature was measured as 416 ± 79 mmHg. This study represents the first known experimental measurement of temperature at the site of vessel sealing found in the literature.
通过直接和间接加热融合生物组织是医学研究的一个新兴领域，但人们对这一过程的理解仍存在很大差距。几家公司已经开发出了融合血管的设备，但对组织对这些刺激的反应知之甚少。为了继续开发和改进能量传输设备，需要对组织融合过程中的组织行为进行准确测量。进行了一项实验研究，以测量组织融合过程中经历的温度和融合动脉的爆裂压力。在猪脾动脉段的管腔中放置了一组热电偶，并使用 ConMed Altrus 热融合设备进行密封。记录了组织内、设备内和组织-设备界面处的温度。然后对这些测量值进行分析，以计算动脉管腔中的温度分布。使用 ConMed Altrus 测量到组织融合部位的动脉温度范围为 142 至 163°C。在该温度下融合的动脉的相应爆裂压力测量值为 416±79mmHg。这项研究代表了文献中首次对血管密封部位温度进行的已知实验测量。
