Department of Neurological Sciences, 982045 University of Nebraska Medical Center, Omaha, Nebraska, 68164, USA.
Muscle Nerve. 2013 Dec;48(6):883-8. doi: 10.1002/mus.23891. Epub 2013 Oct 4.
We evaluated incorporation of the quantitative sudomotor axon reflex test (QSART) into the diagnostic criteria for small fiber neuropathy (SFN) as an addition to quantitative sensory testing (QST) and intraepidermal nerve fiber density (IENFD) testing.
One hundred one patients with clinically suspected SFN underwent QSART, QST, and skin biopsy. The diagnostic yield of existing SFN criteria in these patients was compared with criteria incorporating QSART. The new combined diagnostic criteria were evaluated.
SFN was diagnosed in 38 of the 101 patients (38%) using current criteria. Addition of QSART existing SFN criteria resulted in an increased diagnostic yield to 67 patients (66%). Applying new SFN criteria requiring abnormality in at least 2 assessments among QSART, QST, and IENFD resulted in a diagnosis of SFN in 57 patients (56%).
Assessment of both somatic and peripheral autonomic small nerve fibers enhances diagnostic criteria for SFN.
我们评估了定量出汗反射测试（QSART）纳入小纤维神经病（SFN）诊断标准的情况，将其作为定量感觉测试（QST）和表皮内神经纤维密度（IENFD）测试的补充。
101 例临床疑似 SFN 患者接受 QSART、QST 和皮肤活检。比较这些患者现有 SFN 标准的诊断率与纳入 QSART 的标准。评估新的联合诊断标准。
使用现有标准，101 例患者中有 38 例（38%）诊断为 SFN。在现有 SFN 标准中加入 QSART，诊断率提高至 67 例（66%）。应用新的 SFN 标准，要求 QSART、QST 和 IENFD 中至少有 2 项异常，57 例（56%）患者诊断为 SFN。
评估躯体和周围自主小神经纤维可增强 SFN 的诊断标准。
