Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK.
J Sci Food Agric. 2013 Nov;93(14):3588-94. doi: 10.1002/jsfa.6213. Epub 2013 Jun 12.
The health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100.
None of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively.
These data do not support the notion that these plant bioactives can improve human platelet function.
富含水果和蔬菜的饮食对健康的益处可能部分归因于生物活性植物化学物质对血小板活性的调节。本研究旨在研究富含生物活性的植物提取物和分离的生物活性代谢物对血小板功能的影响。用生物活性丰富的植物提取物处理血液样本（n=15 名受试者），这些植物提取物作为黑海地区的传统食品食用，或者用人源代谢物槲皮素和萝卜硫素处理。使用 PFA-100 评估血小板功能。
含有各种类黄酮、硫代葡萄糖苷和其他生物活性物质的提取物，或槲皮素或萝卜硫素的分离生物活性代谢物，均未导致 PFA-100 闭合时间 (CT) 发生显著变化。相比之下，阳性对照物（阿司匹林和阿昔单抗）分别使血小板激动剂肾上腺素和 ADP 的 CT 持续显著增加。
这些数据不支持这些植物生物活性物质可以改善人类血小板功能的观点。
