Chen Cen, Zhang Qian, Wang Feng-Qin, Li Chun-Hong, Hu Yuan-Jia, Xia Zhi-Ning, Yang Feng-Qing
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, PR China.
Pak J Pharm Sci. 2019 Jan;32(1):185-195.
In the present study, the anti-platelet aggregation activity of 14 vegetables and fruits was tested in vitro. The aqueous, 90% ethanol and ethyl acetate extracts, as well as concentrated juices of 14 foods (fruits and vegetables) were prepared, and the anti-platelet aggregation activity of those extracts was analyzed on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate (ADP), bovine thrombin (THR) and arachidonic acid (AA) as aggregation inducers, respectively. Aspirin (ASP) was used as the positive control. A number of the tested foods had inhibitory effects in concentration-dependent manner on platelet aggregations induced by various agonists. Especially, some foods such as lemon, leek, garlic, scallion, ginger, tomato and grapefruit showed good anti-platelet aggregation effect similar or higher than that of positive control group i.e. aspirin (ASP). The results of present study provide scientific reference for reasonable selection of daily dietary with supplementary curative effects or prevention of cardiovascular diseases (CVD).
在本研究中，对14种蔬菜和水果的抗血小板聚集活性进行了体外测试。制备了14种食物（水果和蔬菜）的水提取物、90%乙醇提取物、乙酸乙酯提取物以及浓缩汁，并分别以5'-二磷酸腺苷（ADP）、牛凝血酶（THR）和花生四烯酸（AA）作为聚集诱导剂，在体外血小板聚集分析仪上分析这些提取物的抗血小板聚集活性。阿司匹林（ASP）用作阳性对照。许多受试食物对各种激动剂诱导的血小板聚集具有浓度依赖性抑制作用。特别是，柠檬、韭菜、大蒜、葱、姜、番茄和葡萄柚等一些食物显示出良好的抗血小板聚集效果，与阳性对照组即阿司匹林（ASP）相似或更高。本研究结果为合理选择具有辅助治疗作用或预防心血管疾病（CVD）的日常饮食提供了科学参考。
