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肽-聚合物缀合物:从基础科学到应用

Peptide-polymer conjugates: from fundamental science to application.

作者信息

Shu Jessica Y, Panganiban Brian, Xu Ting

机构信息

Department of Materials Science and Engineering, University of California, Berkeley, California 94720-1760, USA.

出版信息

Annu Rev Phys Chem. 2013;64:631-57. doi: 10.1146/annurev-physchem-040412-110108. Epub 2013 Jan 16.

Abstract

Peptide/protein-polymer conjugates make up a new class of soft matter comprising natural and synthetic building blocks. They have the potential to combine the advantages of proteins and synthetic polymers (i.e., the precise chemical structure and diverse functionalities of biomolecules and the stability and processability of synthetic polymers) to generate hybrid materials with properties yet to be realized with either component alone. Here we briefly discuss recent developments in the design, fundamental understanding, and self-assembly of various peptide-polymer conjugates, as well as emerging biological and nonbiological applications that range from nanomedicine, to separation, and beyond.

摘要

肽/蛋白质-聚合物共轭物构成了一类新型软物质,其由天然和合成构建块组成。它们有潜力结合蛋白质和合成聚合物的优点(即生物分子精确的化学结构和多样的功能以及合成聚合物的稳定性和可加工性),以生成具有单独任何一种组分都无法实现的性能的杂化材料。在此,我们简要讨论各种肽-聚合物共轭物在设计、基本认识和自组装方面的最新进展,以及从纳米医学到分离等新兴的生物和非生物应用。

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