Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece.
J Clin Periodontol. 2010 Mar;37(3):255-65. doi: 10.1111/j.1600-051X.2009.01530.x.
A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcgamma receptor (FcgammaR) polymorphisms with susceptibility to aggressive and chronic periodontal disease.
A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: FcgammaRIIA H131R (rs1801274), FcgammaRIIIA F158V (rs396991) and FcgammaRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.
The FcgammaRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the FcgammaRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between FcgammaRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between FcgammaRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking).
系统评价和荟萃分析旨在研究 Fcγ 受体（FcγR）多态性与侵袭性和慢性牙周病易感性的潜在关联。
数据库搜索共产生了 17 项研究，涉及 1685 例病例和 1570 例对照。荟萃分析包括 3 种多态性：FcγRIIA H131R（rs1801274）、FcγRIIIA F158V（rs396991）和 FcγRIIIB NA1/NA2。分析采用随机效应模型。比较病例组和对照组等位基因和基因型的分布，计算比值比（OR）及其 95％置信区间（CI）。
FcγRIIIB NA1/NA2 多态性与侵袭性（每等位基因 OR 2.005，95％CI：1.044，3.851）和慢性牙周炎（隐性对比 NA2NA2 与 NA1NA1+NA1NA2 OR 1.397，95％CI：1.039，1.878）相关。分析表明，FcγRIIA H131R 多态性与亚洲人侵袭性牙周炎之间存在弱关联（R 与 H 等位基因 OR 1.579，95％CI：1.025，2.432）。相反，FcγRIIIA F158V 与牙周病之间没有关系。基础研究的累积证据使 FcγRIIIB NA1/NA2 多态性与牙周炎之间的假设关联具有生物学意义。然而，需要进一步研究以评估可能的基因-基因或基因-环境相互作用（例如与吸烟的相互作用）。
