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甲状旁腺素治疗夏科氏关节病踝关节融合术后骨不连

Successful treatment of nonunion with teriparatide after failed ankle arthrodesis for Charcot arthropathy.

机构信息

Osaka City General Hospital, 2-13-22, Miyakojima hondori, Miyakojimaku, Osaka, Japan,

出版信息

Osteoporos Int. 2013 Oct;24(10):2729-32. doi: 10.1007/s00198-013-2367-9. Epub 2013 May 7.

DOI:10.1007/s00198-013-2367-9
PMID:23649801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3777162/
Abstract

We describe a case of successful treatment to nonunion after multiple arthrodesis operations for Charcot arthropathy with teriparatide. We describe the case of a 25-year-old woman with severe Type I diabetes mellitus that resulted in nonunion after multiple arthrodesis operations for Charcot arthropathy. The woman sustained a femoral shaft fracture for which she underwent surgery with intramedullary nail fixation. Immediately after surgery, an empiric course of teriparatide was initiated. Femoral shaft fracture healing was observed after 2 weeks, and the woman was able to walk 12 weeks after the surgery, at which point plain film and computed tomography images revealed complete union of the ankle.

摘要

我们描述了一例使用特立帕肽成功治疗夏科氏关节炎多次关节融合术后骨不连的病例。我们描述了一例 25 岁患有严重 1 型糖尿病的女性患者,由于夏科氏关节炎多次关节融合术后导致骨不连。该女性患者发生股骨干骨折,接受了髓内钉固定手术。术后立即开始经验性特立帕肽治疗。术后 2 周观察到股骨干骨折愈合,患者术后 12 周即可行走,此时 X 线和平扫 CT 显示踝关节完全愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/3777162/6aa622e0f29b/198_2013_2367_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/3777162/6b31180e3367/198_2013_2367_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/3777162/6aa622e0f29b/198_2013_2367_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/3777162/6b31180e3367/198_2013_2367_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7305/3777162/6aa622e0f29b/198_2013_2367_Fig2_HTML.jpg

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Does Teriparatide Improve Fracture Union?: A Systematic Review.特立帕肽是否能促进骨折愈合?一项系统评价。
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