锂可增强人血小板中[3H]CDP-二酰基甘油的激动剂形成。
Lithium potentiates agonist formation of [3H]CDP-diacylglycerol in human platelets.
作者信息
Watson S P, Shipman L, Godfrey P P
机构信息
Department of Pharmacology, Oxford, U.K.
出版信息
Eur J Pharmacol. 1990 Apr 25;188(4-5):273-6. doi: 10.1016/0922-4106(90)90011-l.
PMID:2365013
Abstract
Thrombin stimulated a rapid formation of [3H]CDP-diacylglycerol in platelets prelabelled with [3H]cytidine. This response was increased in the presence of LiCl after a delay of 5 min; potentiation could be prevented by myo-inositol. Since Li+ inhibits the liberation of inositol from inositol phosphates, the conversion of diacylglycerol to phosphatidylinositol via CDP-diacylglycerol may be dependent on the regeneration of inositol from this pathway.
摘要
凝血酶刺激预先用[3H]胞苷标记的血小板中[3H]CDP-二酰甘油的快速形成。在延迟5分钟后，LiCl存在时这种反应增强；肌醇可阻止这种增强作用。由于Li+抑制肌醇从肌醇磷酸酯中释放，通过CDP-二酰甘油将二酰甘油转化为磷脂酰肌醇可能依赖于该途径中肌醇的再生。
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