Department of Pathophysiology, China Medical University, Heping District, Shenyang Liaoning Province, China.
Bioessays. 2013 Aug;35(8):733-43. doi: 10.1002/bies.201200168. Epub 2013 May 7.
The number of cellular events identified as being directly or indirectly modulated by phosphoinositides dramatically increased in the recent years. Part of the complexity results from the fact that the seven phosphoinositides play second messenger functions in many different areas of growth factors and insulin signaling, cytoskeletal organization, membrane dynamics, trafficking, or nuclear signaling. PtdIns(3,4)P2 is commonly reported as a product of the SH2 domain-containing inositol 5-phosphatases 1/2 (SHIP1 and SHIP2) that dephosphorylate PtdIns(3,4,5)P3 at the 5-position. Here we discuss recent interest in PtdIns(3,4)P2 signaling highlighting its involvement in key cellular mechanisms such as cell adhesion, migration, and cytoskeletal regulation. We question and discuss the involvement of SHIP2 either as a PI 5-phosphatase or as a scaffold protein in insulin signaling, cytoskeletal dynamics, and endocytosis of growth factor receptors.
近年来，被鉴定为直接或间接受磷酸肌醇调节的细胞事件数量显著增加。这种复杂性的部分原因是，这七种磷酸肌醇在生长因子和胰岛素信号转导、细胞骨架组织、膜动力学、运输或核信号转导等许多不同领域发挥第二信使功能。PtdIns(3,4)P2 通常被报道为含有 SH2 结构域的肌醇 5-磷酸酶 1/2 (SHIP1 和 SHIP2)的产物，它们在 5 位磷酸化 PtdIns(3,4,5)P3。本文讨论了最近对 PtdIns(3,4)P2 信号的关注，强调了它在细胞黏附、迁移和细胞骨架调节等关键细胞机制中的作用。我们质疑并讨论了 SHIP2 作为 PI 5-磷酸酶或支架蛋白在胰岛素信号转导、细胞骨架动力学和生长因子受体的内吞作用中的作用。
