Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth, Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.
Small. 2013 Oct 25;9(20):3455-61. doi: 10.1002/smll.201202612. Epub 2013 May 6.
Amyloid fibril formation is a critical step in Alzheimer's disease (AD) pathogenesis. Inhibition of Aβ aggregation has shown promising against AD and has been used in clinic trials. Here, a novel strategy is reported for the self-assembly of polyoxometalate-peptide (POM@P) hybrid particles as bifunctional Aβ inhibitors. The two-in-one bifunctional POM@P nanoparticles show an enhanced inhibition effect on amyloid aggregation in mice cerebrospinal fluid. Incorporating a clinically used Aβ fibril-staining dye, congo red (CR), into the hybrid colloidal spheres, the nanoparticles can also act as an effective fluorescent probe to monitor the inhibition process of POM@P via CR fluorescence change in real time. It is believed that such flexible organic-inorganic hybrid systems may prompt the design of new multifunctional materials for AD treatment.
淀粉样纤维形成是阿尔茨海默病（AD）发病机制中的关键步骤。抑制 Aβ聚集已显示出对抗 AD 的前景，并已在临床试验中使用。在这里，报道了一种将多金属氧酸盐-肽（POM@P）杂化颗粒自组装为双功能 Aβ抑制剂的新策略。这种双功能 POM@P 纳米粒子在增强对小鼠脑脊髓液中淀粉样聚集的抑制作用方面显示出优异的性能。将临床上使用的 Aβ纤维染色染料刚果红（CR）掺入杂化胶体球中，纳米粒子还可以作为有效的荧光探针，通过 CR 荧光变化实时监测 POM@P 的抑制过程。相信这种灵活的有机-无机杂化体系可能会促使设计用于 AD 治疗的新型多功能材料。
