Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Int J Mol Sci. 2023 Sep 13;24(18):14044. doi: 10.3390/ijms241814044.
Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects most people worldwide. AD is a complex central nervous system disorder. Several drugs have been designed to cure AD, but with low success rates. Because the blood-brain and blood-cerebrospinal fluid barriers are two barriers that protect the central nervous system, their presence has severely restricted the efficacy of many treatments that have been studied for AD diagnosis and/or therapy. The use of nanoparticles for the diagnosis and treatment of AD is the focus of an established and rapidly developing field of nanomedicine. Recent developments in nanomedicine have made it possible to effectively transport drugs to the brain. However, numerous obstacles remain to the successful use of nanomedicines in clinical settings for AD treatment. Furthermore, given the rapid advancement in nanomedicine therapeutics, better outcomes for patients with AD can be anticipated. This article provides an overview of recent developments in nanomedicine using different types of nanoparticles for the management and treatment of AD.
阿尔茨海默病（AD）是一种影响全球大多数人的进行性神经退行性疾病。AD 是一种复杂的中枢神经系统疾病。已经设计了几种药物来治疗 AD，但成功率较低。由于血脑和血脑脊液屏障是保护中枢神经系统的两个屏障，它们的存在严重限制了许多已研究用于 AD 诊断和/或治疗的治疗方法的疗效。使用纳米颗粒进行 AD 的诊断和治疗是纳米医学这一既定且快速发展的领域的重点。纳米医学的最新进展使得将药物有效递送到大脑成为可能。然而，在 AD 治疗的临床环境中成功使用纳米药物仍然存在许多障碍。此外，鉴于纳米医学治疗学的快速发展，可以预期 AD 患者的治疗效果会更好。本文综述了使用不同类型的纳米颗粒管理和治疗 AD 的纳米医学的最新进展。
