Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Small. 2015 Sep;11(36):4651-5. doi: 10.1002/smll.201501329. Epub 2015 Jul 1.
Chiral recognition plays an important role for biomacromolecules involved self-assembly and further affects their biological functions. Herein, it is demonstrated that two chiral metal complexes can enantioselectively bind with Aβ15-20, leading to the formation of different self-assembled nanostructures. With the ability of both metal complexes and Aβ15-20 to inhibit Aβ1-40 aggregation, the NiM@P hybrid particles can act as bifunctional Aβ inhibitors.
手性识别对于涉及自组装的生物大分子起着重要作用，并进一步影响其生物功能。在此，我们证明了两种手性金属配合物可以对 Aβ15-20 进行对映选择性结合，从而导致形成不同的自组装纳米结构。由于两种金属配合物和 Aβ15-20 都具有抑制 Aβ1-40 聚集的能力，因此 NiM@P 杂化颗粒可以作为双功能 Aβ抑制剂。
