偏头痛的预防药物：聚焦于抗癫痫药物。

Shahien R, Beiruti K

Department of Neurology, Ziv Medical Center, affiliated to Bar Ilan University, Safed 13100, Israel.

J Cent Nerv Syst Dis. 2012 Feb 26;4:37-49. doi: 10.4137/JCNSD.S9049. Print 2012.

Migraine is among the 10 most disabling disorders worldwide. It is characterized by episodes of moderate or severe headaches with various degree of disability, resulting in a considerable health burden upon the sufferers and their family. The objective of this article is to review the use of prophylaxis with antiepileptic drugs. Particular focus is given to their mechanism of action, metabolism, pharmacokinetics, safety profile, efficacy and to provide a summary of the most relevant clinical studies and patient preference.

偏头痛是全球十大致残性疾病之一。其特征为发作性中度或重度头痛，并伴有不同程度的功能障碍，给患者及其家庭带来了相当大的健康负担。本文的目的是综述抗癫痫药物在偏头痛预防中的应用。特别关注其作用机制、代谢、药代动力学、安全性、疗效，并对最相关的临床研究和患者偏好进行总结。