Indian Institute of Technology Bombay (IIT B), Department of Biosciences and Bioengineering, Powai, Mumbai 400076, India.
Expert Opin Drug Deliv. 2013 Aug;10(8):1061-76. doi: 10.1517/17425247.2013.796361. Epub 2013 May 7.
Alginate microspheres are versatile tools for the delivery of a wide range of therapeutic biomacromolecules. This naturally occurring biopolymer has many unique properties making it an ideal candidate for tailoring with different composites of polymers leading to the formation of strong complexes for a broad range of applications.
This article overviews various types of composite alginate microspheres, methods of preparation, new technologies available, physico-chemical characteristics, controlled release profiles, applications and the future directions of composite alginate microsphere delivery system for biomacromolecules.
Composite alginate microsphere systems are the ideal carriers for controlled delivery applications because of their ability to encapsulate a myriad of therapeutic drugs, proteins, enzymes, DNA, antisense oligonucleotides, vaccines, growth factors and chemokines as well as the ease of processing, mechanical properties, biocompatibility, high bioavailability, controlled release rates, stability, suitability for different administration modes, targeted/localized delivery of different agents and large-scale production with cost-effectiveness. This article presents updated information of applying microalginate-based technologies and tools in the biomedical field which will benefit research scientists and clinical physicians or biopharmaceutical industries keen in the development of application-based new therapeutic and diagnostic strategies for various diseases. Furthermore, this technology will play more important roles in biosensors, vaccination, tissue engineering, cancer chemotherapeutics and stem cell research.
海藻酸盐微球是一种多功能工具，可用于输送各种治疗性生物大分子。这种天然存在的生物聚合物具有许多独特的性质，使其成为与不同聚合物复合材料进行定制的理想候选材料，从而形成适用于广泛应用的强复合物。
本文综述了各种类型的复合海藻酸盐微球、制备方法、新出现的技术、物理化学特性、控制释放特性、应用以及复合海藻酸盐微球生物大分子输送系统的未来发展方向。
复合海藻酸盐微球系统是控制释放应用的理想载体，因为它们能够封装各种治疗药物、蛋白质、酶、DNA、反义寡核苷酸、疫苗、生长因子和趋化因子，并且易于加工、具有机械性能、生物相容性、高生物利用度、控制释放率、稳定性、适用于不同的给药方式、靶向/局部输送不同的药物以及具有成本效益的大规模生产。本文介绍了应用微海藻酸盐技术和工具在生物医学领域的最新信息，这将使研究科学家、临床医生或生物制药行业受益，他们热衷于开发各种疾病的基于应用的新治疗和诊断策略。此外，该技术将在生物传感器、疫苗接种、组织工程、癌症化疗和干细胞研究中发挥更重要的作用。
