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用于精准给药的改性藻酸盐：控释和靶向系统的进展

Modified alginates for precision drug delivery: Advances in controlled-release and targeting systems.

作者信息

Masoumi Shahrbabak Sara, Jalali Seyede Melika, Fathabadi Maryam Fadaei, Tayebi-Khorrami Vahid, Amirinejad Mostafa, Forootan Soheil, Saberifar Mahsa, Fadaei Mohammad Reza, Najafi Zohre, Askari Vahid Reza

机构信息

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Int J Pharm X. 2025 Aug 25;10:100381. doi: 10.1016/j.ijpx.2025.100381. eCollection 2025 Dec.

DOI:10.1016/j.ijpx.2025.100381
PMID:40933609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12419010/
Abstract

Alginates have been modified to become a suitable platform for targeted drug release, triggering advances in targeted and controlled-release systems. Alginate chemistry and various structural modifications, including ionic crosslinking, cyclodextrin-linking, and chemical carboxyl and hydroxyl group modification, such as esterification, amidation, and sulfation, are covered in this review. These modifications are aimed at enhancing drug release mechanisms, like dissolution, diffusion, water penetration, and ion exchange-based systems. Application of modified alginates in controlled-release systems is extensive, from hydrogels, bioprinting approaches, nanofiber-based systems, in-situ gelling systems, to nanoparticle systems. Targeted drug delivery utilizes passive and active targeting strategies for numerous applications, including the treatment of cancer, inflammatory disease therapy, infectious disease, and wound healing. Emerging platforms such as hydrogels and nanoparticles provide evidence of the versatility of modified alginates. However, issues regarding scalability and biocompatibility remain as obstacles. In this review, the capabilities of alginate-based delivery systems and their role in making various release mechanisms for targeted delivery are discussed in relation to the future directions for precision medicine development.

摘要

海藻酸盐已被改性，成为靶向药物释放的合适平台，推动了靶向和控释系统的发展。本文综述了海藻酸盐化学及各种结构改性，包括离子交联、环糊精连接以及化学羧基和羟基改性，如酯化、酰胺化和硫酸化。这些改性旨在增强药物释放机制，如溶解、扩散、水渗透和基于离子交换的系统。改性海藻酸盐在控释系统中的应用广泛，涵盖水凝胶、生物打印方法、基于纳米纤维的系统、原位凝胶化系统以及纳米颗粒系统。靶向药物递送利用被动和主动靶向策略用于多种应用，包括癌症治疗、炎症性疾病治疗、传染病治疗和伤口愈合。水凝胶和纳米颗粒等新兴平台证明了改性海藻酸盐的多功能性。然而，可扩展性和生物相容性问题仍然是障碍。在本综述中，基于海藻酸盐的递送系统的能力及其在实现各种靶向递送释放机制中的作用与精准医学发展的未来方向相关进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1730/12419010/0c5af3d70bde/gr8.jpg
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