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How antibiotics kill bacteria: new models needed?

作者信息

Wright Gerard D, Hung Deborah T, Helmann John D

机构信息

M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

出版信息

Nat Med. 2013 May;19(5):544-5. doi: 10.1038/nm.3198.

DOI:10.1038/nm.3198
PMID:23652106
Abstract
摘要

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How antibiotics kill bacteria: new models needed?抗生素如何杀死细菌:需要新模型吗?
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本文引用的文献

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Killing by bactericidal antibiotics does not depend on reactive oxygen species.杀菌抗生素的杀菌作用不依赖于活性氧。
Science. 2013 Mar 8;339(6124):1213-6. doi: 10.1126/science.1232688.
2
Cell death from antibiotics without the involvement of reactive oxygen species.抗生素导致的细胞死亡不涉及活性氧。
Science. 2013 Mar 8;339(6124):1210-3. doi: 10.1126/science.1232751.
3
Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics.杀菌抗生素导致细胞死亡的原因是鸟嘌呤核苷酸库的氧化。
Nat Rev Microbiol. 2021 Feb;19(2):123-132. doi: 10.1038/s41579-020-00443-1. Epub 2020 Oct 6.
4
A Numbers Game: Ribosome Densities, Bacterial Growth, and Antibiotic-Mediated Stasis and Death.一场数字游戏:核糖体密度、细菌生长以及抗生素介导的停滞与死亡
mBio. 2017 Feb 7;8(1):e02253-16. doi: 10.1128/mBio.02253-16.
5
The Role of Reactive Oxygen Species in Antibiotic-Induced Cell Death in Burkholderia cepacia Complex Bacteria.活性氧在洋葱伯克霍尔德菌复合体细菌抗生素诱导的细胞死亡中的作用
PLoS One. 2016 Jul 20;11(7):e0159837. doi: 10.1371/journal.pone.0159837. eCollection 2016.
6
Synthesis of a New Peptide-Coumarin Conjugate: A Potential Agent against Cryptococcosis.一种新型肽-香豆素缀合物的合成:一种潜在的抗隐球菌病药物。
ACS Med Chem Lett. 2015 Jan 7;6(3):271-5. doi: 10.1021/ml500393q. eCollection 2015 Mar 12.
7
Moving forward with reactive oxygen species involvement in antimicrobial lethality.继续探讨活性氧在抗菌致死性中的作用。
J Antimicrob Chemother. 2015 Mar;70(3):639-42. doi: 10.1093/jac/dku463. Epub 2014 Nov 23.
8
Silver enhances antibiotic activity against gram-negative bacteria.银增强了抗生素对革兰氏阴性菌的活性。
Sci Transl Med. 2013 Jun 19;5(190):190ra81. doi: 10.1126/scitranslmed.3006276.
Science. 2012 Apr 20;336(6079):315-9. doi: 10.1126/science.1219192.
4
Antimicrobial treatment of anaerobic infections.抗厌氧感染的抗菌治疗。
Expert Opin Pharmacother. 2011 Aug;12(11):1691-707. doi: 10.1517/14656566.2011.576672. Epub 2011 Apr 21.
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Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death.活性氧物种在喹诺酮类介导的细菌细胞死亡途径中的作用。
J Antimicrob Chemother. 2010 Mar;65(3):520-4. doi: 10.1093/jac/dkp486. Epub 2010 Jan 12.
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A common mechanism of cellular death induced by bactericidal antibiotics.杀菌性抗生素诱导细胞死亡的常见机制。
Cell. 2007 Sep 7;130(5):797-810. doi: 10.1016/j.cell.2007.06.049.
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Genome of the bacterium Streptococcus pneumoniae strain R6.肺炎链球菌R6菌株的基因组。
J Bacteriol. 2001 Oct;183(19):5709-17. doi: 10.1128/JB.183.19.5709-5717.2001.