Obembe O O, Onasanwo S A, Raji Y
Department of Physiology, College of Health Sciences, Osun State University, Osogbo, Nigeria.
Niger J Physiol Sci. 2012 Dec 18;27(2):165-9.
The effects of methanol extract of Buchholzia coriacea seed was studied on male reproductive system of albino rats. Administration of 200mg/kg b.w.(p.o.) of the extract for 6 weeks resulted in significant reduction (P˂0.05) in the weight of the epididymis and seminal vesicle, but not the testes and prostate gland. Also the weight of the visceral organs- lungs, liver, heart and kidney were unaffected. A marked decrease (P<0.05) in sperm motility and volume was also observed in sperm collected from the caudal epididymis of the treated animals. Sperm count and morphology were not significantly affected (P<0.05). Total tissue protein of the epididymis and testes of the treated rats was significantly increased (P<0.05) and fertility was zero in the treated rats. Histological section showed that the epididymal ducts were mostly empty, though the epithelial lining appeared normal. There were fewer spermatozoa and late stage spermatids in the testes, with normal testicular epithelium. The results suggest that the extract of Buchholzia coriacea may have antifertility effects in male rats, the site of action most probably the epididymis.
研究了厚皮布氏豆种子甲醇提取物对白化大鼠雄性生殖系统的影响。以200mg/kg体重（口服）的剂量给予提取物6周，导致附睾和精囊重量显著降低（P˂0.05），但睾丸和前列腺重量未受影响。此外，内脏器官——肺、肝、心和肾的重量也未受影响。在从处理过的动物的附睾尾部收集的精子中，还观察到精子活力和体积显著下降（P<0.05）。精子计数和形态未受到显著影响（P<0.05）。处理过的大鼠附睾和睾丸的总组织蛋白显著增加（P<0.05），且处理过的大鼠生育力为零。组织学切片显示，附睾管大多为空，尽管上皮衬里看起来正常。睾丸中的精子和晚期精子细胞较少，睾丸上皮正常。结果表明，厚皮布氏豆提取物可能对雄性大鼠具有抗生育作用，作用部位很可能是附睾。
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