Obembe Olawale Olaleye
Department of Physiology, College of Health Sciences, Osun State University, Osogbo, Nigeria.
JBRA Assist Reprod. 2019 Oct 14;23(4):408-413. doi: 10.5935/1518-0557.20190047.
Aqueous extract of Moringa oleifera seeds have been reported to exert male reproductive toxicity. To elucidate the spermatoxic constituents, methanol and hexane fractions of Moringa seeds were administered to male rats.
Methanol or hexane fractions (50 and 100 mg/kg) of Moringa seeds were administered orally to male rats for six weeks, while a control group concurrently received the vehicle. Thereafter, sperm profiles were examined on a microscope while sex hormones and antioxidants levels were measured from serum samples.
The methanol fraction of Moringa seeds significantly decreased testosterone, luteinizing hormone, sperm motility, and sperm count of treated rats when compared with controls. The hexane fraction of Moringa seeds had no effect on sex hormones or sperm profiles. Both methanol and hexane fractions significantly increased superoxide dismutase and catalase levels, while malondialdehyde levels decreased significantly.
The methanol fraction - but not the hexane fraction - of Moringa oleifera seeds induced male reproductive toxicity. By its turn, the hexane fraction had a higher antioxidant effect.
据报道，辣木籽水提取物具有雄性生殖毒性。为阐明精子毒性成分，将辣木籽的甲醇和己烷馏分给予雄性大鼠。
将辣木籽的甲醇或己烷馏分（50和100毫克/千克）口服给予雄性大鼠六周，而对照组同时接受赋形剂。此后，在显微镜下检查精子特征，同时从血清样本中测量性激素和抗氧化剂水平。
与对照组相比，辣木籽的甲醇馏分显著降低了受试大鼠的睾酮、促黄体生成素、精子活力和精子数量。辣木籽的己烷馏分对性激素或精子特征没有影响。甲醇和己烷馏分均显著提高了超氧化物歧化酶和过氧化氢酶水平，而丙二醛水平显著降低。
辣木籽的甲醇馏分而非己烷馏分诱导雄性生殖毒性。反过来，己烷馏分具有更高的抗氧化作用。
Zotero 插件
