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功能化核壳型磁性纳米粒子修饰的红细胞:吸附机制的阐明。

Red blood cells decorated with functionalized core-shell magnetic nanoparticles: elucidation of the adsorption mechanism.

机构信息

UPMC University of Paris 06-CNRS-ESPCI Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France.

出版信息

Chem Commun (Camb). 2013 Jun 14;49(47):5393-5. doi: 10.1039/c3cc41513a.

Abstract

The decoration of red blood cells (RBCs) with aminated and carboxylated core-shell magnetic nanoparticles (CSMNs) was studied and elucidated. It was demonstrated that only aminated CSMNs could decorate the RBCs and their adsorption interaction is mainly ruled by electrostatic attraction between the positively charged amino groups on CSMNs and the abundant sialic acid groups on the outer surface of RBCs.

摘要

研究并阐明了用氨基化和羧基化核壳磁性纳米粒子(CSMNs)对红细胞(RBCs)进行修饰的方法。结果表明,只有氨基化的 CSMNs 才能修饰 RBCs,其吸附相互作用主要由 CSMNs 上带正电荷的氨基与 RBC 外表面丰富的唾液酸基团之间的静电吸引所决定。

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