Jia Lina, Zhang Peng, Sun Hongyan, Dai Yuguo, Liang Shuzhang, Bai Xue, Feng Lin
School of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China.
Nanomaterials (Basel). 2021 Oct 21;11(11):2790. doi: 10.3390/nano11112790.
Nanoparticle delivery systems have good application prospects in the treatment of various diseases, especially in cancer treatment. The effect of drug delivery is regulated by the properties of nanoparticles. There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made. This review summarizes the optimization strategies of nanoparticles from three aspects-improving biocompatibility, increasing the targeting efficiency of nanoparticles, and improving the drug loading rate of nanoparticles-aiming to provide some theoretical reference for the subsequent drug delivery of nanoparticles.
纳米颗粒递送系统在各种疾病的治疗中具有良好的应用前景，尤其是在癌症治疗方面。药物递送的效果受纳米颗粒性质的调节。近年来，有许多研究聚焦于优化纳米颗粒的结构，并取得了一系列成果。本综述从改善生物相容性、提高纳米颗粒的靶向效率以及提高纳米颗粒的载药率这三个方面总结了纳米颗粒的优化策略，旨在为纳米颗粒后续的药物递送提供一些理论参考。
