Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
Chem Commun (Camb). 2013 Jun 14;49(47):5375-7. doi: 10.1039/c3cc42420k.
We have developed a new molecular beacon design that requires an additional UV pulse for fluorescence activation. This improves the signal-to-noise ratio tremendously compared to previous approaches and allows for a precise control of the time point and location of RNA labelling.
我们开发了一种新的分子信标设计，该设计需要额外的 UV 脉冲来激活荧光。与以前的方法相比，这极大地提高了信号与噪声的比率，并能够精确控制 RNA 标记的时间点和位置。
