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硝西泮和氟西泮作为镇静剂的双盲试验。

A double blind trial of nitrazepam and flurazepam as sedatives.

作者信息

James N M

出版信息

N Z Med J. 1975 Mar 12;81(535):246-8.

PMID:236528
Abstract

A double-blind cross-over trial was conducted using flurazepam and nitrazepam as sedatives in a group of a dozen psychiatric in-patients. The results show highly significant differences between placebo effects and the active drugs. The differences between the two drugs were not significant apart from the subjective estimate of time slept in which flurazepam was superior. As other studies have confirmed also their safety, relative lack of side effects and very low addictive potential it seems there is little to choose between them, except for the possibility that flurazepam may be preferred subjectively.

摘要

对一组12名精神科住院患者进行了一项双盲交叉试验,使用氟西泮和硝西泮作为镇静剂。结果显示,安慰剂效应与活性药物之间存在高度显著差异。除了在睡眠时间的主观估计上氟西泮更优外,两种药物之间的差异并不显著。由于其他研究也证实了它们的安全性、相对较少的副作用和极低的成瘾潜力,似乎除了主观上可能更倾向于氟西泮外,两者之间几乎没有什么可选择的。

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