Department of Pathology, University of Arizona, Tucson, Arizona, USA.
Prostate. 2013 Aug;73(11):1233-40. doi: 10.1002/pros.22675. Epub 2013 May 7.
This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression.
Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data.
After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+).
This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.
本研究探讨了两种常见遗传改变 ERG 和 PTEN 在前列腺癌进展中的联合效应。
通过免疫组织化学检测 90 例单侧包膜穿透性病变和对侧器官局限性第二病变患者前列腺组织中 TMPRSS2:ERG 转化产物 ERG 的表达和 PTEN 表达缺失情况，PTEN 是一种强大的磷酸酶，可抑制 PI3 激酶通路。采用多变量逻辑回归分析数据。
调整 Gleason 评分后，与野生型（ERG-/PTEN+）相比，ERG+/PTEN-组发生包膜穿透的几率高 5.19 倍（P=0.015）。
本研究首次证明 ERG 过表达和 PTEN 缺失与更大的包膜穿透风险相关。尽管需要进一步研究，但这些结果有可能改变前列腺癌的临床评估。
