1Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Clin Appl Thromb Hemost. 2014 May;20(4):385-92. doi: 10.1177/1076029613486537. Epub 2013 May 7.
Aspirin (ASA) is recommended for the prevention of cardiovascular disease; however, the compliance is low. Reported use may not reflect actual use. Serum thromboxane B2 (STxB2) measurement was evaluated to validate reported ASA use. Males aged 45 to 79 years and females aged 55 to 79 years completed a survey and STxB2 measurement (Thromboxane B2 EIA Kit; Cayman Chemical, Ann Arbor, Michigan). The 107 patients were grouped by use of ASA (56 ASA+ and 51 ASA-) and possible interfering medications (INT) such as nonsteroidal anti-inflammatory drugs. The STxB2 levels (ng/mL) were significantly lower in ASA users: ASA+ INT- 3.0 (0.7, 8.4), ASA+ INT+ 2.0 (0.8, 4.9), ASA- INT+ 176 (75, 390), and ASA- INT- 271 (199, 366). The INT use did not cause a significant difference in STxB2 levels. A STxB2 cut point of 25 ng/mL had high sensitivity (94.1%) and specificity (91.1%) for ASA use. The STxB2 was a reliable marker of ASA use and could be used to confirm ASA exposure in population-based health studies.
阿司匹林（ASA）被推荐用于预防心血管疾病；然而，其依从性较低。报告的使用情况可能并不反映实际使用情况。本研究评估了血清血栓素 B2（STxB2）测量以验证报告的 ASA 使用情况。45 至 79 岁的男性和 55 至 79 岁的女性完成了一项调查和 STxB2 测量（血栓素 B2 EIA 试剂盒；Cayman Chemical，密歇根州安阿伯）。107 名患者按 ASA 使用情况（56 名 ASA+和 51 名 ASA-）和可能的干扰药物（INT）（如非甾体抗炎药）分组。ASA 使用者的 STxB2 水平（ng/mL）明显较低：ASA+INT-3.0（0.7，8.4）、ASA+INT+2.0（0.8，4.9）、ASA-INT+176（75，390）和 ASA-INT-271（199，366）。INT 使用不会导致 STxB2 水平的显著差异。STxB2 截断值为 25ng/mL 时，对 ASA 使用具有高灵敏度（94.1%）和特异性（91.1%）。STxB2 是 ASA 使用的可靠标志物，可用于确认基于人群的健康研究中的 ASA 暴露情况。
