Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Drug Test Anal. 2013 Aug;5(8):607-13. doi: 10.1002/dta.1482. Epub 2013 May 7.
Traditional herbal medicines (THMs) are gaining popularity worldwide as an alternative approach to prescription drugs for many reasons including a general perception that they are safe. But recently there have been number of reported studies that reveal adulteration of THMs with undeclared synthetic drugs, which may potentially cause serious toxic adverse effects. This paper reviews the various classes of synthetic drugs that were found to be adulterated in THMs worldwide. The main focus is to highlight newer analytical tools used to detect adulteration. Due to the advancement in hyphenated techniques like liquid chromatography tandem mass spectrometry (LC-MS/MS), gas chromatography-tandem mass spectrometry (GC-MS/MS) and other conventional tools, it has become possible to detect synthetic drugs and their structural analogues as adulterants even if they are present in small quantities. This review also gives an overview of health-related risks after consuming such spurious products and challenges for future perspectives to control such type of malpractices.
传统草药 (THMs) 由于多种原因在全球范围内越来越受欢迎，成为处方药的替代品，包括人们普遍认为它们是安全的。但最近有许多报道的研究表明，THMs 中掺有未申报的合成药物，这可能会导致严重的毒性不良反应。本文综述了在全球范围内发现的掺有 THMs 的各种合成药物。主要重点是强调用于检测掺假的新分析工具。由于液相色谱串联质谱 (LC-MS/MS)、气相色谱串联质谱 (GC-MS/MS) 等联用技术以及其他常规工具的进步，即使合成药物及其结构类似物以少量存在，也可以检测到作为掺杂物。这篇综述还概述了食用此类假冒产品后的健康相关风险，以及未来控制此类不当行为的挑战。
