Fan Dong-Mei, Tian Xiao-Yu, Wang Rui-Fang, Yu Juan-Juan
The Department of Gynecology, The First Affiliated Hospital of Henan University of Science and Technology, 471023, Luoyang, China.
Tumour Biol. 2014 Nov;35(11):11237-42. doi: 10.1007/s13277-014-2110-y. Epub 2014 Aug 12.
The incidence of stage IbIIa of cervical adenocarcinoma accounts about 60 to 70% of all patients. This study aims to investigate the prognostic significance of protein estrogen receptor alpha (ERα) and transforming growth factor beta 1 (TGF-β1) level in different glandular epithelia of the cervix. In this study, immunohistochemistry was used to detect ERα and TGF-β1 in carcinomas and incisal margins of 66 cases with cervical adenocarcinoma, 20 cases with normal cervix, and 20 cases with chronic cervicitis. Uni- and multivariate analysis was applied to evaluate the prognostic significance of TGF-β1 and ERα in carcinomas. The results indicated that the positive expression of TGF-β1 in carcinomas was 71.21%, significantly higher compared to that in the normal cervix (35%) and chronic cervicitis (55%) (χ(2) = 8.901, P = 0.012). Similarly, the positive expression of ERα in the carcinomas was 68.18%, significantly higher compared to the normal cervix (35%) and chronic cervicitis (50%) (χ(2) = 7.693, P = 0.021). Both TGF-β1 and ERα in the carcinomas were associated with the vaginal recurrence, infection of HPV, depth of infiltration, and lymphatic metastasis (P < 0.05). The conjugation of TGF-β1 and ERα was an independent prognostic factor for cervical adenocarcinoma. Survival curve showed that the positive TGF-β1 and ERα indicated a short lifetime of patient with cervical adenocarcinoma. In conclusion, the expression of TGF-β1 and ERα protein in the carcinomas had a significant prognostic value in a patient of stage IbIIa in cervical adenocarcinoma.
宫颈腺癌IbIIa期的发病率约占所有患者的60%至70%。本研究旨在探讨雌激素受体α（ERα）和转化生长因子β1（TGF-β1）水平在宫颈不同腺上皮中的预后意义。在本研究中，采用免疫组织化学方法检测66例宫颈腺癌、20例正常宫颈和20例慢性宫颈炎患者的癌组织及手术切缘中的ERα和TGF-β1。应用单因素和多因素分析评估TGF-β1和ERα在癌组织中的预后意义。结果表明，癌组织中TGF-β1的阳性表达率为71.21%，显著高于正常宫颈（35%）和慢性宫颈炎（55%）（χ(2)=8.901，P=0.012）。同样，癌组织中ERα的阳性表达率为68.18%，显著高于正常宫颈（35%）和慢性宫颈炎（50%）（χ(2)=7.693，P=0.021）。癌组织中的TGF-β1和ERα均与阴道复发、HPV感染、浸润深度和淋巴转移相关（P<0.05）。TGF-β1与ERα的联合是宫颈腺癌的独立预后因素。生存曲线显示，TGF-β1和ERα阳性表明宫颈腺癌患者生存期较短。总之，癌组织中TGF-β1和ERα蛋白的表达对IbIIa期宫颈腺癌患者具有显著的预后价值。
