Zhang Hong, Han Shufen, Cao Pei, Zhai Chengkai
Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Wei Sheng Yan Jiu. 2013 Mar;42(2):190-5.
To study the effects of four kinds of experimental diet, including high fat/cholesterol diet, Chinese wild rice diet, white rice-flour diet and basal diet on the lipotoxicity and disordered lipid metabolism in rats.
44 male SD rats were divided into four groups, the basal group, high fat/cholesterol diet group, white rice-flour group and Chinese wild rice group. All rats of four groups were given different diets. Body weights were measured every week, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), free fatty acids (FFA) and leptin concentrations were measured, and liver pathology were observed.
When compared with the basal diet group, the hyperlipidemic rat model was successfully made in high fat/cholesterol diet group. When compared with the high fat/cholesterol diet group and white rice-flour diet group, the serum TG and TC contents were significantly decreased (P < 0.05), and HDL-C concentration significantly increased (P < 0.05) in Chinese wild rice group. Moreover, Chinese wild rice group had lower contents of serum and liver FFA than those of the high fat/cholesterol diet group and white rice-flour diet group (P < 0.05). Although Chinese wild rice group had a lower serum leptin level than the high fat/cholesterol diet group and white rice-flour diet group, there was no significant differences among the three groups (P > 0.05). The conditions of liver cell fatty degeneration in Chinese wild rice group were slight.
Compared to the white rice-flour diet, Chinese wild rice could improve the lipid metabolism and liver lipotoxicity of hyperlipidemic rats induced by high fat/cholesterol diet.
研究高脂/胆固醇饮食、菰米饮食、白米粉饮食和基础饮食这四种实验性饮食对大鼠脂毒性及脂质代谢紊乱的影响。
将44只雄性SD大鼠分为四组，即基础组、高脂/胆固醇饮食组、白米粉组和菰米组。四组大鼠均给予不同饮食。每周测量体重，检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、游离脂肪酸（FFA）和瘦素浓度，并观察肝脏病理情况。
与基础饮食组相比，高脂/胆固醇饮食组成功建立了高脂血症大鼠模型。与高脂/胆固醇饮食组和白米粉饮食组相比，菰米组血清TG和TC含量显著降低（P<0.05），HDL-C浓度显著升高（P<0.05）。此外，菰米组血清和肝脏FFA含量低于高脂/胆固醇饮食组和白米粉饮食组（P<0.05）。虽然菰米组血清瘦素水平低于高脂/胆固醇饮食组和白米粉饮食组，但三组间差异无统计学意义（P>0.05）。菰米组肝细胞脂肪变性情况较轻。
与白米粉饮食相比，菰米可改善高脂/胆固醇饮食诱导的高脂血症大鼠的脂质代谢及肝脏脂毒性。
