Giersiepen M, Wurzinger L J, Opitz R, Reul H
Helmholtz-Institut für Biomedizinische Technik an der RWTH Aachen, F.R.G.
Int J Artif Organs. 1990 May;13(5):300-6.
The hemodynamics of heart valve prostheses can be reproducibly investigated in vitro within circulatory mock loops. By measuring the downstream velocity and shear stress fields the shear stresses which are clinically responsible for damage to platelets and red blood cells can be determined. The mechanisms of damage and the effects of shear stresses on blood corpuscles were investigated by Wurzinger et al. at the Aerodynamics Institute of the RWTH Aachen. In the present study, the above data are incorporated into a mathematical correlation, which serves as a basic model for the estimation of blood damage. This mathematical model was applied to in vitro investigations of 25 different aortic valve prostheses. The results were compared to clinical findings. In most cases agreement was good, indicating that this model may be directly applied to the clinical situation. This new method facilitates the estimation of clinically expected blood damage from in vitro measurements. It may be useful for the development and evaluation of new valve prostheses. By comparative evaluation of different valve types it also provides additional information to help the implanting surgeon select the optimum valve for his patient.
心脏瓣膜假体的血流动力学可以在体外循环模拟回路中进行可重复的研究。通过测量下游速度和剪切应力场，可以确定临床上导致血小板和红细胞损伤的剪切应力。Wurzinger等人在亚琛工业大学空气动力学研究所研究了损伤机制以及剪切应力对血细胞的影响。在本研究中，上述数据被纳入一个数学关联式，该关联式作为估计血液损伤的基本模型。这个数学模型被应用于对25种不同主动脉瓣假体的体外研究。将结果与临床发现进行了比较。在大多数情况下，一致性良好，表明该模型可以直接应用于临床情况。这种新方法有助于从体外测量中估计临床上预期的血液损伤。它可能对新型瓣膜假体的开发和评估有用。通过对不同瓣膜类型的比较评估，它还提供了额外的信息，以帮助植入外科医生为其患者选择最佳瓣膜。
