一种新型海洋来源放线菌中的生物活性氨基苯并吩嗪酮生物碱。

A new bioactive aminophenoxazinone alkaloid from a marine-derived actinomycete.

机构信息

a Chemistry Department , Faculty of Science, Helwan University , Ain Helwan, Cairo , Egypt.

出版信息

Nat Prod Res. 2013;27(22):2126-31. doi: 10.1080/14786419.2013.793686. Epub 2013 May 9.

DOI:10.1080/14786419.2013.793686

Abstract

Chemical investigation of the marine Streptomyces sp. Eg25 led to the isolation of one new natural 2-aminophenoxazin-3-one-8-carboxylic acid methyl ester named maroxazinone (1) as well as the known compounds elloxazinone A (2), exfoliazone (3), carboxyexfoliazone (4), elloxazinone B (5) and venezueline D (6). The chemical structures of the isolated compounds were deduced from extensive studies of NMR ((1)H and (13)C NMR, (1)H-(1)H COSY, HMQC and HMBC) and mass spectra. The cytotoxic activities of the new maroxazinone (1) and venezueline D (6) against breast carcinoma cell line (MCF7), liver carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) were investigated.

摘要

海洋放线菌 Eg25 的化学研究导致分离出一种新的天然 2-氨基苯并恶嗪-3-酮-8-羧酸甲酯，命名为马罗嗪酮（1），以及已知化合物埃洛嗪酮 A（2）、脱皮唑（3）、羧基脱皮唑（4）、埃洛嗪酮 B（5）和委内瑞拉素 D（6）。从 NMR（(1)H 和 (13)C NMR、(1)H-(1)H COSY、HMQC 和 HMBC）和质谱的广泛研究中推导出分离化合物的化学结构。对新的马罗嗪酮（1）和委内瑞拉素 D（6）对乳腺癌细胞系（MCF7）、肝癌细胞系（HEPG2）和结肠癌细胞系（HCT116）的细胞毒性活性进行了研究。