State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
Bioorg Med Chem Lett. 2013 Jan 1;23(1):301-4. doi: 10.1016/j.bmcl.2012.10.096. Epub 2012 Oct 30.
Five new phenoxazine-based alkaloids venezuelines A-E (1-5) and two new aminophenols venezuelines F-G (6-7), as well as three known analogues exfoliazone, chandrananimycin D and carboxyexfoliazone were isolated from the fermentation broth of the marine-derived bacterium Streptomyces venezuelae. The structures of new compounds were determined on the basis of extensive spectroscopic analysis. The cytotoxic activity of these compounds against a panel of tumor cell lines were tested, while the regulation of gene target Nur77 of 2 and exfoliazone (8) were evaluated.
从海洋来源的链霉菌属（Streptomyces venezuelae）发酵液中分离得到五个新的 phenoxazine 生物碱 venezuelines A-E（1-5）和两个新的 aminophenols venezuelines F-G（6-7），以及三个已知类似物 exfoliazone、chandrananimycin D 和 carboxyexfoliazone。新化合物的结构是基于广泛的光谱分析确定的。测试了这些化合物对一系列肿瘤细胞系的细胞毒性活性，同时评估了 2 和 exfoliazone（8）的基因靶标 Nur77 的调节。
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