International College of Medicine, Thammasat University, Bangkok, Thailand.
Expert Rev Clin Pharmacol. 2013 May;6(3):307-22. doi: 10.1586/ecp.13.17.
Emergence of artemisinin resistance has been confirmed in Cambodia and the border areas of Thailand, the well-known hotspots of multidrug resistance Plasmodium falciparum. It appears to be spreading to the western border of Thailand along the Thai-Myanmar border, and will probably spread to other endemic areas of the world in the near future. This raises a serious concern on the long-term efficacy of artemisinin-based combination therapies, as these combination therapies currently constitute the last effective and most tolerable treatment for multidrug-resistant Plasmodium falciparum. Attempts have been made by a diverse array of stakeholders to prevent the emergence of new foci of artemisinin resistance, as well as to limit the spread of resistance to the original foci. The success in achieving this goal depends on effective integration of containment and surveillance programs with other malaria control measures, with support from both basic and operational research.
青蒿素耐药性的出现已在柬埔寨和泰国边境地区得到证实，这些地区是著名的多重耐药性恶性疟原虫热点地区。它似乎正在沿着泰缅边境向泰国西部边境蔓延，并可能在不久的将来传播到世界其他流行地区。这对青蒿素为基础的联合疗法的长期疗效提出了严重关切，因为这些联合疗法目前是治疗多重耐药性恶性疟原虫的最后一种有效和最耐受的治疗方法。各种利益攸关方已经做出了努力，以防止青蒿素耐药性新焦点的出现，并限制耐药性向原焦点的传播。实现这一目标的成功取决于将遏制和监测计划与其他疟疾控制措施有效结合，并得到基础和业务研究的支持。
