腈的一锅法合成 2,5-二取代嘧啶。
One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles.
机构信息
Chemical Development US, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States.
出版信息
J Org Chem. 2013 Jun 7;78(11):5800-3. doi: 10.1021/jo400720p. Epub 2013 May 22.
PMID:23656541
Abstract
A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.
摘要
介绍了一种 2,5-二取代嘧啶合成的实用、一步法。该方案被证明对合成各种含有各种官能团的嘧啶类化合物是通用的。
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