Department of Geriatrics, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University Xi'an, Xi'an, China.
APMIS. 2014 Feb;122(2):140-6. doi: 10.1111/apm.12107. Epub 2013 May 8.
Glycoprotein nonmetastatic melanoma B (GPNMB) is a type I transmembrane glycoprotein which is overexpressed in many tumors and seems to play a critical role in metastasis of malignant tumors. The purpose of this study was to determine GPNMB expression in small cell lung cancer (SCLC) and analyze the prognostic value in patients with SCLC. A total of 132 cases of SCLCs were analyzed immunohistochemically on tissue microarrays (TMAs). Patients were divided into weak-positive and strong-positive GPNMB groups. In addition, serum GPNMB was evaluated by enzyme-linked immunosorbent assay (ELISA). The average serum GPNMB concentration was 1054.15 ± 363.71 pg/mL in the weak-positive group, 2611.52 ± 457.57 pg/mL in the strong-positive group, and 427.61 ± 273.9 pg/mL in the control. The strong-positive group showed significantly higher serum GPNMB levels than the weak-positive group and healthy control (p < 0.01). Overall survival in the weak-positive GPNMB group was significantly longer than in the strong-positive group (27 months vs 15 months, p < 0.01). These results suggest that the expression of GPNMB may be useful as a prognostic indicator in patients with SCLC.
糖蛋白非转移性黑素瘤 B（GPNMB）是一种 I 型跨膜糖蛋白，在许多肿瘤中过度表达，似乎在恶性肿瘤的转移中发挥关键作用。本研究旨在确定小细胞肺癌（SCLC）中 GPNMB 的表达，并分析其对 SCLC 患者的预后价值。通过组织微阵列（TMA）对 132 例 SCLC 进行免疫组织化学分析。将患者分为弱阳性和强阳性 GPNMB 组。此外，通过酶联免疫吸附试验（ELISA）评估血清 GPNMB。在弱阳性组中，血清 GPNMB 的平均浓度为 1054.15 ± 363.71 pg/mL，在强阳性组中为 2611.52 ± 457.57 pg/mL，在对照组中为 427.61 ± 273.9 pg/mL。强阳性组的血清 GPNMB 水平明显高于弱阳性组和健康对照组（p < 0.01）。弱阳性 GPNMB 组的总生存时间明显长于强阳性组（27 个月 vs 15 个月，p < 0.01）。这些结果表明，GPNMB 的表达可能可用作 SCLC 患者的预后指标。
