Department of Dermatology, Peking University People's Hospital, Beijing, China.
Chin Med J (Engl). 2012 Sep;125(18):3279-82.
Glycoprotein non-metastatic melanoma protein B (GPNMB) plays an important role in the pathogenesis of inflammatory and malignant diseases. We investigated the expression of GPNMB in benign and malignant skin diseases.
Tissue microarray was performed in the skin tissues of 102 cases including malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and benign dermatosis. The expression of GPNMB in the tissues was detected by immunohistochemistry. Twenty cases of normal skin and adjacent neoplastic normal skin tissues were selected as controls.
GPNMB was positively stained in skin malignancies (38/50, 76%), which was significantly higher than that in the control and the benign skin tissues (P = 0.001 and < 0.001 respectively). GPNMB was positively stained in MM (13/15, 87%) and SCC (16/20, 80%) (P < 0.001). Significant higher expression of GPNMB was observed in patients aged ≥ 65 years than those less than 65 years (n = 11 and n = 9 respectively, P = 0.027). No significant difference of the expression rates was observed between normal control and BCC; however, stronger intensity was detected in the latter. Negative or weak expression was observed in the controls.
Over-expression of GPNMB correlated strongly and might play an important role in the pathogenesis of MM and SCC.
糖蛋白非转移性黑色素瘤蛋白 B（GPNMB）在炎症性和恶性疾病的发病机制中发挥重要作用。我们研究了 GPNMB 在良性和恶性皮肤疾病中的表达。
对 102 例皮肤组织进行组织微阵列分析，包括恶性黑色素瘤（MM）、鳞状细胞癌（SCC）、基底细胞癌（BCC）和良性皮肤病。采用免疫组织化学法检测组织中 GPNMB 的表达。选择 20 例正常皮肤和相邻肿瘤正常皮肤组织作为对照。
GPNMB 在皮肤恶性肿瘤（38/50，76%）中呈阳性染色，明显高于对照组和良性皮肤组织（P = 0.001 和 <0.001）。GPNMB 在 MM（13/15，87%）和 SCC（16/20，80%）中呈阳性染色（P <0.001）。在年龄≥65 岁的患者中，GPNMB 的表达水平明显高于年龄<65 岁的患者（n = 11 和 n = 9，P = 0.027）。正常对照组和 BCC 之间的表达率无显著差异，但后者的表达强度更强。对照组呈阴性或弱阳性表达。
GPNMB 的过度表达与 MM 和 SCC 的发病机制密切相关，可能发挥重要作用。
