表皮中的ADAM17对于Notch激活并非必需。 - Suppr

Epidermal ADAM17 is dispensable for notch activation.

作者信息

Groot Arjan J, Cobzaru Cristina, Weber Silvio, Saftig Paul, Blobel Carl P, Kopan Raphael, Vooijs Marc, Franzke Claus-Werner

出版信息

J Invest Dermatol. 2013 Sep;133(9):2286-8. doi: 10.1038/jid.2013.162. Epub 2013 Apr 3.

DOI:10.1038/jid.2013.162

PMID:23657465

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3745798/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7657/3745798/5df5a7760c8d/nihms462119f1.jpg

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Epidermal ADAM17 is dispensable for notch activation.表皮中的ADAM17对于Notch激活并非必需。

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本文引用的文献

J Exp Med. 2012 Jun 4;209(6):1105-19. doi: 10.1084/jem.20112258. Epub 2012 May 7.

Immunity. 2012 Jan 27;36(1):105-19. doi: 10.1016/j.immuni.2012.01.005.

Proteolytic cleavage of Notch: "HIT and RUN".Notch 的蛋白水解切割：“击中并逃逸”。

Curr Mol Med. 2011 Jun;11(4):255-69. doi: 10.2174/156652411795677972.

Development. 2011 Feb;138(3):495-505. doi: 10.1242/dev.055210.

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.ADAM10 是原代神经元中淀粉样前体蛋白的生理相关、组成性的α-分泌酶。

EMBO J. 2010 Sep 1;29(17):3020-32. doi: 10.1038/emboj.2010.167. Epub 2010 Jul 30.

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.特应性皮炎样疾病和相关致死性骨髓增生性疾病源于小鼠皮肤中 Notch 信号的缺失。

PLoS One. 2010 Feb 18;5(2):e9258. doi: 10.1371/journal.pone.0009258.

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.金属蛋白酶ADAM10是Notch1位点2切割所必需的。

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The canonical Notch signaling pathway: unfolding the activation mechanism.经典Notch信号通路：揭示激活机制

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Epidermal ADAM17 is dispensable for notch activation.

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