Jarosz Magdalena, Latosiński Jakub, Gumułka Paweł, Dąbrowska Monika, Kępczyński Mariusz, Sulka Grzegorz Dariusz, Starek Małgorzata
Department of Physical Chemistry & Electrochemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, Poland.
Pharmaceutics. 2023 Jul 1;15(7):1861. doi: 10.3390/pharmaceutics15071861.
Considering the potential of nanostructured titanium dioxide layers as drug delivery systems, it is advisable to indicate the possibility of creating a functional drug delivery system based on anodic TiO for celecoxib as an alternative anti-inflammatory drug and its inclusion complex with β-cyclodextrin. First, the optimal composition of celecoxib-β-cyclodextrin complexes was synthesized and determined. The effectiveness of the complexation was quantified using isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR) nuclear magnetic resonance (H NMR), and scanning electron microscopy (SEM). Then, nanostructured titanium dioxide layers (TiO) were synthesized using the electrochemical oxidation technique. The TiO layers with pore diameters of 60 nm and layer thickness of 1.60 µm were used as drug delivery systems. The samples were modified with pure celecoxib and the β-cyclodextrin-celecoxib complex. The release profiles shown effective drug release from such layers during 24 h. After the initial burst release, the drug was continuously released from the pores. The presented results confirm that the use of nanostructured TiO as a drug delivery system can be effectively used in more complicated systems composed of β-cyclodextrin-celecoxib complexes, making such drugs available for pain treatment, e.g., for orthopedic surgeries.
考虑到纳米结构二氧化钛层作为药物递送系统的潜力，建议指出基于阳极TiO为塞来昔布（一种替代抗炎药物）及其与β-环糊精的包合物创建功能性药物递送系统的可能性。首先，合成并确定了塞来昔布-β-环糊精复合物的最佳组成。使用等温滴定量热法（ITC）、差示扫描量热法（DSC）、红外光谱（FT-IR）、核磁共振（H NMR）和扫描电子显微镜（SEM）对络合的有效性进行了量化。然后，采用电化学氧化技术合成了纳米结构二氧化钛层（TiO）。孔径为60nm、层厚为1.60μm的TiO层用作药物递送系统。样品用纯塞来昔布和β-环糊精-塞来昔布复合物进行了改性。释放曲线显示，在24小时内药物从这些层中有效释放。在初始突释后，药物从孔隙中持续释放。给出的结果证实，将纳米结构TiO用作药物递送系统可有效地用于由β-环糊精-塞来昔布复合物组成的更复杂系统中，使此类药物可用于疼痛治疗，例如用于骨科手术。
