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Ti-13Nb-13Zr生物医学合金上氧化物纳米管的生物活性和血栓形成特性

Biological Activity and Thrombogenic Properties of Oxide Nanotubes on the Ti-13Nb-13Zr Biomedical Alloy.

作者信息

Stróż Agnieszka, Gawlikowski Maciej, Balin Katarzyna, Osak Patrycja, Kubisztal Julian, Zubko Maciej, Maszybrocka Joanna, Dudek Karolina, Łosiewicz Bożena

机构信息

Institute of Materials Engineering, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland.

Faculty of Biomedical Engineering, Silesian University of Technology, 40 Roosevelt, 41-800 Zabrze, Poland.

出版信息

J Funct Biomater. 2023 Jul 18;14(7):375. doi: 10.3390/jfb14070375.

DOI:10.3390/jfb14070375
PMID:37504870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10382023/
Abstract

The success of implant treatment is dependent on the osseointegration of the implant. The main goal of this work was to improve the biofunctionality of the Ti-13Nb-13Zr implant alloy by the production of oxide nanotubes (ONTs) layers for better anchoring in the bone and use as an intelligent carrier in drug delivery systems. Anodization of the Ti-13Nb-13Zr alloy was carried out in 0.5% HF, 1 M (NH)SO + 2% NHF, and 1 M ethylene glycol + 4 wt.% NHF electrolytes. Physicochemical characteristics of ONTs were performed by high-resolution electron microscopy (HREM), X-ray photoelectron spectroscopy (XPS), and scanning Kelvin probe (SKP). Water contact angle studies were conducted using the sitting airdrop method. In vitro biological properties and release kinetics of ibuprofen were investigated. The results of TEM and XPS studies confirmed the formation of the single-walled ONTs of three generations on the bi-phase (α + β) Ti-13Nb-13Zr alloy. The ONTs were composed of oxides of the alloying elements. The proposed surface modification method ensured good hemolytic properties, no cytotoxity for L-929 mouse cells, good adhesion, increased surface wettability, and improved athrombogenic properties of the Ti-13Nb-13Zr alloy. Nanotubular surfaces allowed ibuprofen to be released from the polymer matrix according to the Gallagher-Corrigan model.

摘要

种植体治疗的成功取决于种植体的骨整合。这项工作的主要目标是通过制备氧化纳米管（ONTs）层来改善Ti-13Nb-13Zr种植体合金的生物功能，以便更好地锚固在骨中，并用作药物递送系统中的智能载体。Ti-13Nb-13Zr合金在0.5%HF、1M（NH）SO + 2%NHF以及1M乙二醇 + 4wt.%NHF电解质中进行阳极氧化。通过高分辨率电子显微镜（HREM）、X射线光电子能谱（XPS）和扫描开尔文探针（SKP）对ONTs的物理化学特性进行了表征。采用坐滴法进行水接触角研究。研究了布洛芬的体外生物学特性和释放动力学。透射电子显微镜（TEM）和XPS研究结果证实，在双相（α + β）Ti-13Nb-13Zr合金上形成了三代单壁ONTs。ONTs由合金元素的氧化物组成。所提出的表面改性方法确保了Ti-13Nb-13Zr合金具有良好的溶血性能、对L-929小鼠细胞无细胞毒性、良好的粘附性、增加的表面润湿性以及改善的抗血栓形成性能。纳米管表面可使布洛芬根据加拉格尔-科里根模型从聚合物基质中释放出来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3318/10382023/d5826d654f4a/jfb-14-00375-g010.jpg
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本文引用的文献

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Materials (Basel). 2023 Jan 31;16(3):1237. doi: 10.3390/ma16031237.
3
Semi-Quantitative Method of Assessing the Thrombogenicity of Biomaterials Intended for Long-Term Blood Contact.
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Materials (Basel). 2022 Dec 21;16(1):38. doi: 10.3390/ma16010038.
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Int J Nanomedicine. 2022 Apr 29;17:1865-1879. doi: 10.2147/IJN.S362720. eCollection 2022.
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