Department of Biochemistry, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla 689 101.
J Biosci. 2013 Jun;38(2):385-9. doi: 10.1007/s12038-013-9313-z.
Coronary artery disease (CAD) is a multifactorial disease caused by the interplay of environmental risk factors with multiple predisposing genes. The present study was undertaken to evaluate the role of DNA repair efficiency and oxidative stress and antioxidant status in CAD patients. Malonaldehyde (MDA), which is an indicator of oxidative stress, and mean break per cell (b/c) values, which is an indicator of decreased DNA repair efficiency, were found to be significantly increased in patients compared to normal controls (P less than 0.05) whereas ascorbic acid and GSH were found to be lower among patients than the control group. It has been found that elevated oxidative stress decreased antioxidant level and decreased DNA repair efficiency can contribute to the development of CAD. This study also showed that high MDA, low ascorbic acid and GSH were significantly associated with high b/c value.
冠状动脉疾病（CAD）是一种由环境风险因素与多种易患基因相互作用引起的多因素疾病。本研究旨在评估 DNA 修复效率和氧化应激及抗氧化状态在 CAD 患者中的作用。与正常对照组相比，患者的丙二醛（MDA），这一氧化应激的指标，以及平均每个细胞的断裂数（b/c）值，这一 DNA 修复效率降低的指标，均显著升高（P 小于 0.05），而患者的抗坏血酸和 GSH 水平则低于对照组。已经发现，氧化应激的升高降低了抗氧化水平，降低了 DNA 修复效率，这可能导致 CAD 的发生。本研究还表明，高 MDA、低抗坏血酸和 GSH 与高 b/c 值显著相关。
